{"id":5649,"date":"2026-10-31T12:00:47","date_gmt":"2026-10-31T15:00:47","guid":{"rendered":"https:\/\/overticeportal.com.br\/?p=5649"},"modified":"2026-10-31T12:00:52","modified_gmt":"2026-10-31T15:00:52","slug":"japao-inicia-transplante-de-celulas-tronco-para-tratar-parkinson","status":"publish","type":"post","link":"https:\/\/portalam9.com.br\/?p=5649","title":{"rendered":"Jap\u00e3o inicia transplante de c\u00e9lulas-tronco para tratar Parkinson"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>Tempo de leitura: 2 minutos<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Um paciente recebeu, pela primeira vez, um transplante de c\u00e9lulas-tronco para tratar a doen\u00e7a de Parkinson no Jap\u00e3o. O procedimento foi realizado neste m\u00eas de outubro, no Hospital Universit\u00e1rio de Quioto, ap\u00f3s a aprova\u00e7\u00e3o condicional da terapia no pa\u00eds. A informa\u00e7\u00e3o foi divulgada pela farmac\u00eautica Sumitomo Pharma, respons\u00e1vel pelo tratamento.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A t\u00e9cnica utiliza c\u00e9lulas-tronco pluripotentes induzidas, conhecidas como iPS, produzidas a partir de c\u00e9lulas adultas de pessoas saud\u00e1veis. Elas s\u00e3o modificadas em laborat\u00f3rio para se transformar em c\u00e9lulas precursoras dos neur\u00f4nios que produzem dopamina, subst\u00e2ncia que participa do controle dos movimentos e fica em falta em pessoas com Parkinson.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A proposta \u00e9 repor parte das c\u00e9lulas perdidas com a doen\u00e7a,<\/strong> em vez de apenas controlar os sintomas.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Como funciona o tratamento<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As iPS s\u00e3o obtidas a partir de c\u00e9lulas adultas que t\u00eam uma fun\u00e7\u00e3o definida no organismo. Em laborat\u00f3rio, os pesquisadores fazem essas part\u00edculas voltarem a um est\u00e1gio semelhante ao das c\u00e9lulas jovens, com capacidade de se transformar em diferentes tipos de tecido.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">No tratamento para Parkinson, elas s\u00e3o direcionadas para se tornarem precursoras de neur\u00f4nios produtores de dopamina. Depois, milh\u00f5es dessas c\u00e9lulas s\u00e3o implantadas no c\u00e9rebro do paciente.<br><br>A doen\u00e7a de Parkinson provoca a perda progressiva de neur\u00f4nios respons\u00e1veis pela produ\u00e7\u00e3o de dopamina. A redu\u00e7\u00e3o da subst\u00e2ncia prejudica a comunica\u00e7\u00e3o entre \u00e1reas do c\u00e9rebro envolvidas no controle dos movimentos e pode causar tremores, rigidez muscular e lentid\u00e3o.\u00a0Os tratamentos dispon\u00edveis ajudam a controlar esses sintomas, <strong>mas n\u00e3o interrompem a progress\u00e3o da doen\u00e7a.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Estudo acompanhou sete pacientes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A aprova\u00e7\u00e3o da terapia no Jap\u00e3o ocorreu em mar\u00e7o, depois de resultados de um ensaio cl\u00ednico com sete pacientes entre 50 e 69 anos. Os participantes receberam implantes de cinco ou 10 milh\u00f5es de c\u00e9lulas em cada lado do c\u00e9rebro.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Durante dois anos de acompanhamento, os pesquisadores n\u00e3o identificaram efeitos adversos graves. <strong>Quatro dos sete pacientes apresentaram melhora nos sintomas.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os resultados fizeram parte do processo que levou \u00e0 autoriza\u00e7\u00e3o condicional do tratamento no pa\u00eds. A aprova\u00e7\u00e3o permite que a terapia seja utilizada, mas est\u00e1 vinculada \u00e0s condi\u00e7\u00f5es estabelecidas pelas autoridades japonesas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A Sumitomo Pharma informou que pretende realizar transplantes em 20 a 30 pacientes at\u00e9 mar\u00e7o de 2029. A farmac\u00eautica tamb\u00e9m conduz um ensaio cl\u00ednico nos Estados Unidos para avaliar a terapia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Apesar dos resultados iniciais, o tratamento ainda precisa ser acompanhado em mais pacientes para que os pesquisadores avaliem a seguran\u00e7a e efic\u00e1cia ao longo do tempo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Foto: FG Trade\/ Getty Images | Fonte: Metr\u00f3poles<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tempo de leitura: 2 minutos Um paciente recebeu, pela primeira vez, um transplante de c\u00e9lulas-tronco<\/p>\n","protected":false},"author":3,"featured_media":5650,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51],"tags":[39],"class_list":["post-5649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-destaque"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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